This is in accordance with the lead-likeness concept proposed earlier [19] which states that leads should be simple, low molecular weight molecules and thus, should fall well within Lipinski's universe.
The obtained taxonomy is assessed using semantic similarity measures, which consist in quantifying the likeness between two concepts or words.
We call this approach the bioactive natural compound-likeness (BNC-likeness) approach, drawing a parallel to the concept of drug-likeness.
The recent public availability of the human metabolome and natural product datasets has revitalized "metabolite-likeness" and "natural product-likeness" as a drug design concept to design lead libraries targeting specific pathways.
But as deployed by corporations against many thousands of individual consumers and employees, it bears a troubling likeness to the 19th-century concept of conciliation as a practice suited only for a subservient underclass.
In light of the controversy of depicting Muhammad's likeness, we can consider the concept of idolatry in Islam.
Given the amount of ink shed on kafala in the last decade by organizations like Human Rights Watch, it's unlikely anyone contracting with the country would be new to the concept or its likeness to slavery (a comparison made even by the Labor Minister of Bahrain, whose country banned the practice only in 2008).
There is a growing body of literature describing the properties of marketed drugs, the concept of drug-likeness and the vastness of chemical space.
A further refinement of the concept of drug-likeness is required for compound libraries intended for central nervous system (CNS) targets to account for the limitations imposed by blood brain barrier permeability.
The concept of drug-likeness, established from the analyses of the physiochemical properties or/and structural features of existing small organic drugs or/and drug candidates, has been widely used to filter out compounds with undesirable properties, especially poor ADMET (absorption, distribution, metabolism, excretion, and toxicity) profiles.
The grille, like those of many recent Buick concepts, bears an unmistakable likeness to the one on the legendary 1938 Buick Y-Job designed by Harley Earl.
