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Each CheA homolog, together with the other cognate che gene products, is likely to regulate a separate chemotaxis-like pathway.
Due to its unique sequence derived from the prrF1-prrF2 intergenic region, PrrH is likely to regulate a specific subset of genes, possibly involved in heme biogenesis or other cellular processes.
Modern interpretations of Von Baer's third law have focused on another, non-mutually exclusive mechanism: genes implicated in early aspects of development are more likely to regulate a large number of downstream effectors via hierarchical regulatory cascades, and are thus more evolutionarily constrained due to the large deleterious pleiotropic effects of mutations.
However, a single miRNA is likely to regulate a biological process by targeting more than one involved gene, and co-expressed clusters of miRNAs have been reported to cooperatively control the members of the same biochemical pathway or even of the same protein complex [ 37].
Regardless of elements of h i for Y(− i ), we note only which element of h i for X(− k i *) has a nonzero value first assuming that the corresponding candidate SNP to h ij is more likely to regulate a target gene i if h ij for a row vector of X(− k i *) has nonzero value earlier than other elements of h i during λ decreases.
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The mixture of a cytokine inhibitor (infliximab) and an inhibitor of cell proliferation (methotrexate) is likely to regulate or even co-regulate a complex set of genes; this is a limitation if an understanding of some underlying events in RA is desired.
Third, the ARGOS family is likely to regulate signal output from a primary rather than a peripheral element of the pathway, because modulation of ARGOS family expression has broad effects on the physiological and molecular response to ethylene.
For example, CNSs located several hundred kbp to a gene is less likely to regulate that gene as a proximal promoter element.
Recent studies have shown that BPS has comparable anti-androgenic effects and is likely to regulate estrogenic transcription at a level comparable to estrogen itself [ 11, 12].
However, the intracellular signalling pathways that are altered by NGF withdrawal - the MLK-JNK-c-Jun pathway is activated and the PI3K-Akt and Raf-MEK-ERK pathways are inactivated - are likely to regulate the expression of a much larger number of genes.
Additionally, various experimental studies have confirmed that gene-proximal (i.e., Flank10kb class) lncRNAs are likely to regulate their coding genomic neighbor in a cis-regulatory or in a trans-regulatory manner.
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