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It is also more likely to be tolerable for people with pain that is aggravated by movement.
Therefore further dose escalation of HCQ is not likely to be tolerable for prolonged periods of time, but future studies could consider a higher loading dose strategy to expedite time to peak concentrations and achievement of steady-state concentrations.
The analysis reveals that (1) physiochemical considerations alone cannot predict which mutations are likely to be rare on an evolutionary timescale, and (2) the phylogenetic context is critical to evaluating whether a given mutation is likely to be tolerable.
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One key factor is likely to be the tolerable deformation for mobilizing but not destroying the strength of the rock mass.
The SYNERGY study aims to provide proof-of-concept data to elucidate whether altering the microbiota in the CKD population is likely to be effective, tolerable and can impede the processes associated with CVD and CKD progression.
A large majority of women (87.2%) found the side effects to be tolerable or easily tolerable.
The majority of women (87.2%) found the side effects to be tolerable or easily tolerable.
Both treatments were shown to be tolerable and safe.
The dose tested in our study is likely to be the maximum tolerable dose.
It has been thought that one key advantage of using microRNAs therapeutically is that they are already expressed at high levels in normal tissues, thus making increased dosing likely to be safe and tolerable.
Faster employment growth, the Fed seems to think, is not likely to be consistent with a tolerable rate of inflation.This is America's recovery.
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