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Tumour cells are mutants and while they proliferate far more than they ought, they are much more susceptible to damage and much less likely to be repaired successfully than surrounding healthy tissue.
However, when the cytosine in CpG sites is methylated, deamination of methylcytosine produces thymine, which cannot be recognized as foreign and thus less likely to be repaired [ 2].
In a BRCA1/2 defective background these DSBs are likely to be repaired by more error-prone repair mechanisms, causing chromosome aberrations and loss of viability [ 54].
First, it is possible that the types of fistula that are more likely to be repaired abdominally (i.e. ureteric, trigonal or supratrigonal) are, in fact, more likely to have a better repair prognosis than fistulas more likely to be repaired vaginally (i.e. urethral fistulas).
This unexpected transitional bias observed in comparative genomic studies is traditionally attributed to mutational bias, whereby transitions are either more likely to occur or less likely to be repaired than transversions.
This is attributed to the ability of α-particles to induce multiple ionizations within the DNA structure and in adjacent molecules, resulting in severe locally damaged sites that are less likely to be repaired 4, 18.
Similar(52)
"From plush to plastic, we fix it," Mr. Chais said in 1993, pointing out that he was as likely to be repairing a 19th-century automaton as a Barbie.
Dr. Robert Michler, surgeon in chief at Montefiore Medical Center in the Bronx, said that if he is in the operating room in the middle of the night, he is very likely to be repairing a torn aorta.
And she underscored her belief that the "corrosive trend of winner-take-all politics" won't likely be able to be repaired from within.
Your master boot record likely got damaged and needs to be repaired.
But if there is an underlying bone problem in the hip joint that needs to be repaired, the likely rehabilitation period will be four months, and his likely return will be in late July.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com