Experiments showed that coexpression patterns mined from multiple independent microarray datasets are more likely to be functionally relevant and thus improve gene function predictions [ 1].
These increases are likely to be functionally relevant as post-pubertal NVH lesioned rats displayed enhanced functional and behavioral responses to systemic administration of the muscarinic agonist, oxotremorine.
High-throughput gene expression data can predict gene function through the "guilt by association" principle: coexpressed genes are likely to be functionally associated.
Such shared or related function supports the hypothesis that bi-directional genes are more likely to be functionally associated than uni-directional genes.
The Cornell researchers became involved at the analysis stage in order to make predictions about what types of changes are most likely to be functionally important.
The pH profiles of activity and stability of the two recombinant cathepsins was shown to differ, differences that are likely to be functionally important and reflect the environments into which the cathepsins are expressed in vivo.
The supramolecular presentation of GAG chains, along with other matrix components, is likely to be functionally important but remains challenging to control and to characterize, both in vivo and in vitro.
This means that a patient who is discharged to their home after critical illness is highly likely to be functionally impaired, and therefore, requires care-giving assistance from a family member.
The genes which co-express together under the subsets of experimental conditions are likely to be functionally similar [14].
A tear that appears to involve most of the ACL fibres is likely to be functionally complete, and we encourage reporting the tear in this fashion.
Conclusions on the basis of indicator values are typically made answering the question of whether numerical values are higher or lower than before, and rarely in terms of whether the differences are likely to be functionally significant.
