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Some scaling aspects of REST are likely not necessary for such settings, and the REST constraints might have side effects that could be avoided if some of RESTs constraints were lifted.
While for most gene therapy applications, a 100% repair is likely not necessary (Chao et al., 2003), one would expect that in the context of cancer therapy, a higher efficiency is essential to prevent clonal expansion of single tumor cells that escape treatment.
However, if you eat plenty of protein throughout the day, it is most likely not necessary to use protein powder.
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But he argues that it would likely not be necessary.
War likely was not necessary to eliminate this great evil from America.
Amputations are so common in Jordan's overworked, underfunded health sector that they are seen as the likely, if not necessary, outcome of a serious limb injury.
It is likely, although not necessary, that it resides in the P body.
Because these genes are not conserved, they likely are not necessary for the metabolism of m-galactarate.
Not likely, but also not necessary.
Consequently, it is important to provide a relevant model of how the patient's OCD is maintained and what must be done to interrupt the contingencies that maintain obsessive-compulsive behavior patterns (although patients/parents often desire to know a specific cause, this is likely not possible or necessary for behavioral intervention).
Therefore, it is likely that it is not necessary to run the two different energy auctions.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com