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Interestingly, we found that TfCel5A active site could only partly rebalance its conformational dynamics upon substrate dissociation within the same simulation time, which implies that the conformational rebalance upon substrate dissociation is likely more difficult than the conformational selection upon substrate binding at least in the view of the time required.
The reaction of hydroxyl groups located in the proximity of the core of the hyperbranched architecture is most likely more difficult than transformation of the ones present at the periphery.
While successful, widespread de-adoption of these practices will require additional research to design and implement tailored KT interventions, the objective nature of this list is important as promoting the de-adoption of established practices is likely more difficult than promoting the adoption of new evidence-based practices.
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Furthermore, the higher number of secreted enzymes allows A. nidulans to utilize a wider variety of substrates present in soil or plant debris, which are likely more difficult to degrade than those available in animal hosts.
Given that high quality autism brain tissue, and in particular pediatric tissue, is likely more difficult to acquire than any other neurological or psychiatric disorder, novel methods such as the one presented here are necessary to shed light on the underlying neuropathological basis of aberrant brain connectivity in this disorder.
Each new vote in the German Parliament, the Bundestag, is likely to be more difficult than the last.
Instead, it's one that reflects General Craddock's view that future relations with Russia are likely to be more difficult than at any time since the Cold War.
Oxidation of copernicium from its neutral state is also likely to be more difficult than those of previous group 12 members.
Patients might also be recruited through outreach, though this is likely to be more difficult than passively receiving patients in a setting where an opportunity for interaction exists.
Although some researchers have suggested that the regulation of autophagy may be a potential therapeutic strategy for AMD prevention or therapy, targeting a process as complex as autophagy is likely to be more difficult than previously thought.
These suppositions agree with our chemical intuition; hydroxylation of PCP is likely to be more difficult than elimination of HCl from the unstable hydroxylation product and electron transfer to TCBQ from an electron donor at the active site.
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