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Allelic R is the squared correlation between allele dosage of the most likely imputed genotype and allele dosage of the true imputed genotype [ 5] and the closer these are, the more accurate the imputation is for the SNP.
These probabilities were directly incorporated into downstream statistical analyses within PLINK, rather than taking the most likely imputed genotype.
When more than one diplotype was possible for an individual, only the most likely imputed haplotypes were used in this analysis.
The SNP concordance rates, which were defined as fraction of identical genotypes between the most likely imputed and observed, were 0.9858 for EA and 0.9805 for AA (filtering imputed genotypes at posterior probability ≥ 0.9).
Pertinent to this study, GCTA was carried out using untransformed peer problem scores in each cohort and the most likely imputed as well as direct genotypes from autosomal SNPs (ALSPAC: NSNPs = 2,449,665, MAF ≥ 0.01, imputation accuracy MACH- R > 0.3; TEDS: NSNPs = 1,588,650 (MAF ≥ 0.01 and INFO > 0.7 score).
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As a matter of fact, such methods will more likely impute a negative (positive) response to a patient who's observed score is low (high) and consequently falsely amplify the distance between individuals on the latent trait scale.
They would instead grow more likely to impute bad motives or pathologies to people on the right.
However, when study subjects did not reveal a fear of black people generally, they were more likely to impute greater competence to taller black men.
This is to be expected, because all methods that are likely to impute one allele correctly are unlikely to impute both alleles incorrectly.
In winner-takes-all, after the clean speech is imputed for each Gaussian belonging to state s, the mixture's likelihood is evaluated for all imputed values and the most likely imputation is selected as the imputation of the state.
The thresholds for these selection criteria were chosen so that monomorphic SNPs and SNPs that are likely to be imputed incorrectly were removed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com