Exact(1)
NOELs may, however, help to locate the dose range in which a biological threshold likely exists, that is, a biological threshold for a given effect is generally assumed to be greater than its NOEL but lower than its Lowest-Observed-Effect-Level (LOEL).
Similar(59)
Of course, other naturally occurring polymorphisms likely exist that are not contained in the Perlegen SNP database and could also lead to false positive associations.
Such analysis will help to identify when informal intelligence is less likely to be influenced by potential bias or when significant gaps in epidemic data likely exist that may necessitate supplementation with other sources.
As penetration of the method into nonacademic sectors where confidentiality is necessary is also at an all-time high, many more applications of this method likely exist that have not been reported in the literature.
TFEB is phosphorylated in over 10 sites (Dephoure et al, 2008; Mayya et al, 2009; Yu et al, 2011), and mechanisms likely exist that drive TFEB into the nucleus independently of the activation state of mTORC1.
No world agreement has been signed to outlaw biological weapons, meaning it is more likely stocks exist that could be pilfered by terrorists.
Overall, these results suggest that ReKINect is capable of predicting NAMs that constitutively activate or inactivate protein kinases and that, in addition to BRAF V600E, numerous other similar mutations are likely to exist that directly affect the catalytic activity of kinases in cancer signaling.
These iterative searches also recovered several borderline hits (e-values ~ 0.05-.2) which shared a conserved motif with the known HEPN domains, suggesting that additional, divergent HEPN domains were likely to exist that might be difficult to detect using the standard iterative search strategies alone.
Because we suspected that multiple, unannotated transcript isoforms of the same gene likely exist, tags that mapped to different positions within the same gene were not combined.
Future clinical trials are required to address these issues as well as the biologic heterogeneity that likely exists between patients who are seemingly cured by surgery, relapse early (<1 year), or at later times following adjuvant therapy.
In particular, there likely exists an intermediate range that might belong to both regimes.
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