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Because the cox1 gene is conserved among all chlorophyte mtDNAs and because its product, the first subunit of the mitochondrial cytochrome oxidase, is likely essential to the mitochondrion, we expected the trans-splicing of this intron to occur at the mRNA level so that a functional protein could be produced.
These events are likely essential to fibrosis in UUO.
The balanced regulation of these target genes by FOXC1 is likely essential to achieve homeostasis within a system.
Thus, we concluded that the rhamnose group found in quercitrin is most likely essential to the antivenom activities of this flavonoid against C. d. terrificus sPLA2.
Moreover, child and adolescent involvement in creating, refining and pilot-testing the curriculum is likely essential to maximize the relevance and developmental appropriateness of its components and the timing of their implementation.
This phenomenon has occurred in several MMTV-PyV mT/MMTV-Cre recombinase backgrounds as demonstrated by our own laboratory: conditional ablation of β1-integrin, focal adhesion kinase, c-Src or Stat3 was prevented, indicating that in each case the conditional gene was most likely essential to PyV mT-driven tumourigenesis [ 5- 7] (unpublished observations; Ranger JJ, Muller WJ).
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The fact that these modules are enriched for ID genes, lncRNAs, and known pathways in ID disorders suggests that these modules are likely essential contributors to normal cognitive development.
Moreover, targeting the underlying mechanisms of pancreatic cancer with more specific agents will likely be essential to substantially improve the survival of patients with this disease as standard cytotoxic agents have shown limited benefit.
Functional changes associated with metabolic processes are likely essential for the adaptation to high-elevation environments.
Therefore, maintaining optimal blood glucose control is likely essential in patients with DN to prevent continued nerve injury.
In addition to the likely essential targets PKG, CDPK1, and the ancestral FIKK kinase, these include CDPK4.
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