Sentence examples for likely efficacious from inspiring English sources
Given ∼50% BACE1 suppression generally accepted as it is likely efficacious, we used BACE1+/− mice as a model system to evaluate the efficacies of partial and therapeutic inhibition of BACE1.
Future randomized control studies of rapamycin combined with chemotherapy in dogs with osteosarcoma can inform our understanding of how best to use rapalogs in microscopic disease, their most likely efficacious setting.
Rotigotine, bromocriptine, oxycodone, carbamazepine, valproic acid, and clonidine were considered likely efficacious.
In the rat model of CMT1A different measures of effectiveness suggested that PXT-3003 walsolso promising and likely efficacious.
While these modifications are likely efficacious, they are associated with high technical complexity and expensive costs of production.
The PBPK assessment would give an estimate of the likely efficacious Cmax concentrations and highlight the potential for a drug drug interaction with a CYP3A inhibitor.
Agonist compounds, on the other hand, would likely be efficacious due to the widespread presence of NPY receptors but could therefore have severe pleiotropic effects.
Considering the relationship between in vitro potency and concentration achieved in mice, compounds with a Cmax/TRE of ≥30, AUC0 48/TRE of ≥587, and T>TRE of 100% would likely be efficacious and would be prioritized for further studies.
"You have to be very careful about instituting treatment for something when you know from first principles that the treatment is not likely to be efficacious".
The goal of most POC trials is to determine whether a treatment is likely to be efficacious for a given indication and thus whether it is worth investing the financial resources and participant exposure necessary for a confirmatory trial of that intervention.
Also, we are well positioned to take care of our loved ones: our efforts are more likely to be efficacious than if we were to attempt to benefit persons distant from us whom we do not know and people often experience greater emotional harm when they are slighted by their intimates than when they are slighted by strangers.
