Sentence examples for likely disruptive from inspiring English sources

We further categorized these mutations using the CooVar program according to their likely disruptive effect on protein structure as based on the Grantham matrix (Grantham 1974; Vergara et al. 2012).

A homozygous mutation completely removing the start codon of the evolutionary conserved LAMC2 wildtype transcript is highly likely disruptive and almost certainly negates completely the presence of a functional LAMC2 protein.

Thus, all the available evidence points at an important role of residue 852U (m.1499T) in the mitoribosome and argue for a likely disruptive role for the U to C transition at this position.

(33, 34) It seems likely that disruptive mutations lead directly to the acquisition of malignant phenotype, whereas non-disruptive mutations, in concert with other events targeting the p53 pathway such as transcriptionally active HPV, might produce a synergistic effect of p53 functional abrogation.

Dr. Kernberg said that a visit by angry relatives "would likely be disruptive for the child, who demands a quiet period of emotional healing from the last few weeks of stress".

Further improvements in patient outcomes will likely require disruptive advances in systemic therapy.

8– 10 CNVs in the genomic regions of these lncRNAs likely cause disruptive effects through the alteration of gene copy number, thereby leading to aberrant expression and possible downstream effects.

They found, that despite girls being much less likely to develop disruptive behaviour disorder (low prevalence), the same factors predicted disruptive behaviour problems in both girls and boys.

This is particularly likely where the "disruptive innovation" does not greatly change the cost structure or end-user experience.

Although oversimplifying Christensen's concepts, early diversifications are likely to deliver disruptive innovation, whereas late diversifications tend to produce sustaining innovations.

Visual representations, such as depictions of women gossiping in church, also reinforced the message that women's speech was likely to be disruptive and deviant.