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"These structures are most likely defective [virus] particles that don't contain the full-length Ebola genome," says Vincent Deubel of the Pasteur Institute in Paris, who announced his group's findings at an institute retreat.
Bowers believes that the returned pieces were likely defective, rather than unsold.
Guided by our comparative gene family classification strategy, we identified six gene models in C. briggsae and C. remanei that are likely defective, causing artificially inflated numbers of ABC transporter genes reported by TRIBE-MCL in these species.
Although we did not investigate processing in Atg-deficient MECs, it is quite likely defective, given the emerging literature mentioned above.
These protection mechanisms are likely defective in tumor cells with self-sufficiency in growth signals and constitutively activated PI3K Akt pathway [ 50, 59].
The swollen mitochondria observed in the VCP RNAi expressing muscles are likely defective and should be a prime target for mitophagy-dependent degradation.
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In addition, it is also likely that defective matrix composition compromises the function of associated growth factors (e.g., Wnts) that are needed for proper chondroblast maturation [22] [24].
Thus, shits1 is likely modestly defective at 18°C and this impairment grows with increasing temperature until a threshold is reached at which paralysis is evident when driven in motorneurons.
It is most likely that defective DNA MMR may play a role in generating genetic diversity and drug resistance in malaria parasites.
It is likely that defective HR in BRCA1/2-mutant tumour cells also underlies their hypersensitivity to IR and DNA crosslinking agents, which may ultimately impact on the chances of combination cancer therapy to achieve tumour eradication.
It is likely that defective proteins are somehow rendered unattainable to the proteasome, even though the cell is able to recognize the defect and tag it for destruction via ubiquitination.
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CEO of Professional Science Editing for Scientists @ prosciediting.com