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Docking simulations suggested that these probes likely bind to the same binding site as IMPY, which was a thin hydrophobic groove parallel to the fibrillar axis formed by VAL 18 and PHE 20.
In this work, we performed prospective docking-based virtual screening to identify small molecules that likely bind to the β-OG binding site.
Genetic analysis showed that UBXN2A binds to mot-2's substrate binding domain, and it partly overlaps p53's binding site indicating UBXN2A and p53 likely bind to mot-2 competitively.
Based on our previous studies, SELPs tended to assemble into micellar-like particles with silk blocks buried in the core, thus, the hydrophobic compounds likely bind to the silk blocks.
The compounds among these proteins that are likely bind to the target protein are selected as the members of the candidate-hit compound group.
Since the membrane of apoptotic, hypoxic and ischemic cells depolarised, annexin V and lactadherin most likely bind to these cells with a higher affinity than to cells with preserved membrane potential.
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The fact that a T. gondii protein can bind to MTs in a "foreign" environment, the cytosol of mammalian cells, suggests that TgICMAP1 likely binds to the MTs directly rather than through other MT binding proteins.
Our structural investigations indicate that ATP likely binds to both rings simultaneously and that a misfolded substrate acts as the trigger for ATP hydrolysis.
This histamine likely binds to H1R and H2R which may then alter the permeability of brain capillaries resulting in the loss of BBB integrity.
Therefore, the recovered PrPC is not cell associated but most likely binds to other proteins or lipids resulting in stable molecular complexes.
It can be deduced from the annotated genome sequence of KT71T that heme a is most likely bound to a cytochrome caa3 oxidase (Table S1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com