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Increased likelihood of transformation that's both significant and enduring.
Given the likelihood of transformation for advanced dysplasia, a recommended treatment for premalignancy is the surgical excision of high risk lesions [ 7, 8].
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Thus, at least over the range examined, variations in the level of immune capacity had no effect upon the likelihood of a transformation in any papilloma, but transformation was directly associated with the incidence of papillomas.
Our challenge, then, is to identify strategies that increase the likelihood of positive transformation.
Overall, we established a key role of MYC as tumor reprogramming factor by guiding the acquisition of stem cell-like traits, thereby increasing the likelihood of neoplastic transformation upon further oncogenic insults.
Here, we take advantage of the wealth of experimental data available on the canonical RAS/RAF/MEK/ERK pathway of Bhalla et al. to test the utility of a newly developed nonlinear analysis algorithm designed to predict likelihood of cellular transformation.
Such losses or gains of these potential growth- or cancer-promoting genes may increase the likelihood of malignant transformation with the accumulation of later mutations.
HQ exposure and pre-existing increased Ras signaling could increase the likelihood of leukemic transformation.
It has been suggested that the size of the nuclei of epithelial basal cells can be used in predicting the likelihood of malignant transformation of epithelium.
Mutations in checkpoint pathways can permit the survival or continued growth of cells with genomic abnormalities, thus enhancing the likelihood of malignant transformation [ 103].
In our experience, high bone tracer uptake in relationship to chondroid-matrix lesions increases the likelihood of malignant transformation but is not specific for malignancy.
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CEO of Professional Science Editing for Scientists @ prosciediting.com