Nonetheless, it is useful to collect some cost data because intervention costs may affect the likelihood of replication.
First, only two tests were used to compute estimates of across-test IIV; this decision was based on the data available and to increase likelihood of replication in future studies.
Circumstances that enhance the likelihood of replication fork collapse could increase mtDNA deletion formation rates.
Reduced fork velocity likely increases the number of origins that are activated, as it reduces the likelihood of passive replication by a fork emanating from a nearby origin.
We suggest that the slow fork progression in mrc1 deleted cells reduces the likelihood of passive replication leading to the activation of origins that remain mostly dormant in wild-type cells.
The likelihood of re-replication for β cells in PDL tail was >100% for each of the labeling protocols in contrast to β cell proliferation in neonatal mice and other models.
Because the network consists of over 900 labs skilled in the techniques necessary for replicating the experiments within the chosen studies, the likelihood of a failed replication due to lack of relevant expertise is minimized.
Over time, this continuous repair of the ovarian epithelial tissue increases the likelihood of errors during replication, potentially leading to carcinogenesis.
This hairpin structure places the chromosomal regions adjacent to the elements involved into close physical proximity, increasing the likelihood of DSB, recombination, and replication slippage on the regions flanking the stem loop structure.
Further whole genome investigation, coupled with studies on individual DNA molecules, will be useful to identify DNA elements and their associated chromatin features including, epigenetic modifications, participation in higher order structures, and function in regulating gene expression which enhance the likelihood of forming an active replication initiation complex.
In our in silico analysis of FluMap, we exploited a specific aspect of the network called controllability to identify molecules that, when inhibited, increase the likelihood of deregulating the virus replication cycle.
