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Incorporating probe sequences expected to hybridize within these polymorphic sites have a greater likelihood of interacting with regions outside of the HLA-B exons.
Similar to the AUC, the CI measure provides a convenient performance metric in cases where it is more important to predict the relative order of labels than their exact values, for instance, when ranking the compounds (or targets) according to their increased likelihood of interacting with a given target (or compound).
For example, sequences in the 3'UTR seem to be more free of constraints in comparison with the 5'UTR to mutate towards a very similar nucleotide composition to the rest of the genome, increasing the likelihood of interacting with other sequences in the genome due to complementarity.
This post-hoc analysis of a 3-year prospective, observational study demonstrated that failure to achieve remission at study enrollment was associated with increased symptoms of schizophrenia, increased healthcare costs, worse HRQOL and functional outcomes, and a greater likelihood of interacting with the criminal justice system.
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Given the need to prioritize large numbers of chemicals for expensive animal-based bioassays, applying ToxCast results toward the identification of chemicals with high likelihoods of interacting with these pathways is a logical prioritization step.
Hence, it is reasonable to believe that the likelihood of employers interacting with ex-offenders is higher in big cities than in small cities, in low-skilled than in high-skilled occupations, and in male-dominated than in female-dominated occupations.
These methods commonly rely on the observation that the products of genes that are associated with similar diseases have a higher likelihood of physically interacting [ 11].
Patients were scheduled for individual appointments in the research clinic to avoid any overlapping appointments to reduce the likelihood of patients interacting and discussing treatment efficacy or side effects while in the waiting room.
The manuscript describes the application of the pseudo-likelihood approach, first described by Balakrishnan et al. (2011), to the determination of interacting residues across protein-protein interfaces.
Here is the sequence of interacting events.
What is the likelihood of two receptors interacting with a single ligand on the cell surface?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com