Naïve Bayes likelihood ORF filtering should eliminate many dubious classifications, but does not provide any information about the age of the transfer event.
A number of filtering methods for fundamental frequency estimation have been considered in this paper, namely the classical comb filtering and maximum likelihood methods along with some more recent methods based on optimal filtering.
Maximum Likelihood analyses of each type of filtered dataset.
One random tree from this set of filtered trees was used for dating using the penalized likelihood method (PL) implemented in the r8s software [ 102].
To define a positive hit and to reduce the likelihood of false positives, we filtered candidate substrates using a signal-to-noise (SNR) threshold method.
Making the conservative assumption that replicate peaks separated by more than 65 bp have an increased likelihood of being spurious, we filtered the peaks from the two samples using this cutoff, resulting in 1608 high-confidence peaks (Additional file 3).
However, the likelihood of clogging makes sand filters less desirable than woodchip filters.
The extended likelihood data association filters those measurements that belong to the target from a clutter of other noisy measurements analysed within the validation gate.
In order to increase the likelihood of successful docking, ligands were filtered by molecular weight and flexibility.
We primarily report results filtered at a likelihood of 50%, but results are comparable across a range thresholds tested, from 25%to90%0% (see, Supplementary Material online).
