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Many C4 evolutionary clusters likely share an ancestor that had already acquired an elevated likelihood of evolving the pathway.
Consequently, the rate of clonal evolution within an individual tumour may change over time, and so the likelihood of evolving a mutator phenotype may change over time.
For s d ≥ 0.01, deleterious selection against housekeeper mutations had negligible impact on the likelihood of evolving a cancer with a mutator phenotype or on the waiting time to cancer (Fig. S1).
We suggest that both the potential for discrete phenotypic variation despite random mating and the larger effectiveness of assortative mating may increase the likelihood of evolving assortative mating and sympatric speciation.
The rarity of gene duplication, coupled with the low likelihood of evolving new combinations of transcription factor binding sites before the duplicated gene is nonfunctionalized by random mutations in coding sequences, should therefore make the process of duplication and recruitment of genes encoding physiological or body proteins into the venom gland exceedingly rare.
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A number of models have been applied to predict the likelihood of populations evolving under climate change.
This would suggest that that there is a greater likelihood of syndactyly evolving in peramelemorphs and diprotodontians due to shared ancestral developmental patterns.
Alternatively, extensive genetic heterogeneity may increase the likelihood of resistance evolving and therefore predict increased risk of relapse (Maley et al, 2006).
Figure 6 shows the process of evolving the likelihood during a RPMCMC run.
Assuming a hereditary basis, one question from evolutionary psychology is why genes that increase the likelihood of psychosis evolved, assuming the condition would have been maladaptive from an evolutionary point of view.
However, the likelihood of such evolved mechanisms remains largely unexplored.
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