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The likelihood of dose adjustment was not influenced by the method of GFR determination or the dosing equation used to determine initial renal function-based dosing.
Adjusting for covariates, patients with severe CKD had a significantly higher likelihood of dose titration compared to allopurinol users without CKD (odds ratio [OR] 2.130, 95% confidence interval [95% CI]: 1.380 - 3.289).
Age and gender were not significant predictors of dose escalation, although the likelihood of dose escalation increased by 4% with every additional $1,000 of RA-related pretreatment costs.
Although there was no significant difference in likelihood of dose titration between all patients with CKD vs. those without CKD (p = 0.45), patients with Stage 4 CKD were significantly more likely to have a dose titration compared to patients without CKD (p < 0.0001).
Similar(56)
Cmp 2A is likely to have a human dose <500 mg, whereas the other compounds have a medium likelihood of a dose >1,000 mg.
Vancomycin was associated with the highest likelihood of major dose deviations, reflecting difficulties in adopting more recent and probably more controversial dosing recommendations of an agent known to have significant side effects [ 38].
On top of that, it had significantly reduced accumulation in the kidney, reducing the likelihood of the dose limiting nephrotoxicity characteristic of cidofovir (9).
Given the likelihood of a dose-response relationship somewhere below 20 mL/kg per hour, delivery of doses lower than this should be avoided [ 22].
A higher likelihood of missed doses was found among patients who were single, self-employed, and in the poor group (vs. the poorest).
Specifically each 1-unit increase in SCr level was associated to an increase in the likelihood of appropriately adjusting dose of medications by a factor of 129.95.
Another study in Ontario revealed that older age was associated with a greater likelihood of receiving a dose lower than evaluated in trials, although there was no difference by sex in this study [ 3].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com