Sentence examples for likelihood of causality from inspiring English sources
When applied to other risk factors in coronary heart disease, this approach has previously confirmed the causal relevance of low density lipoprotein cholesterol, 9 increased the likelihood of causality for Lp(a) lipoprotein, 10 and reduced the likelihood of causality for fibrinogen.
We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality.We assessed the -1131T>C (rs662799) promoter polymorphism of the apolipoprotein A5 (APOA5) gene in relation to triglyceride concentration, several other risk factors, and risk of coronary heart disease.
17 This supports the biological plausibility of our findings and further reinforces the likelihood of causality.
The primary outcome was the development of cefepime neurotoxicity, with the likelihood of causality ascribed via a modified Delphi method.
Thus, it is logical to assume that risk-associated regulatory SNPs would have a higher likelihood of causality if they disrupt or create a motif for a site-specific TF in the nucleosome-free region of an enhancer or DHS.
To discern between these scenarios, we used a two-step approach; we first tested for a link between splicing and gene expression when accounting for the effects of genetics, to subsequently assess the direction of this link by comparing the likelihood of each causality model44 (Methods; Supplementary Fig. 6; Supplementary Note 3).
A sensitivity test was conducted to rule out the likelihood of reverse causality.
A major strength of the VDPP is the prospective design, thereby reducing the likelihood of reverse causality.
The longitudinal nature of the study and the use of medical records reduced the likelihood of reverse causality and recall bias.
Individuals were further stratified by age, diabetes status, and lifestyle status for subgroup multivariable analyses and sensitivity tests to control for confounding effects and likelihood of reverse causality.
The BioCycle study however, excluded women on a diet for weight loss or for other medical reasons rendering the likelihood of reverse causality less likely to occur.
