Exact(4)
From two different analyses of genes up-regulated in the Igf1−/− cochlea a possible binding site for the MEF2 transcription factor was identified with the strongest likelihood of alignment.
However, as the number of duplicate measures increases, so too does the likelihood of alignment instability.
To reduce the likelihood of alignment artifacts as a result of ambiguities, only the commonly predicted alignments from the two programs were used in further analyses.
Denoting r n = (r n (1 ), r n (2 ) ), the likelihood of alignment is computed as (3) P (r n | T m ) = P (l | T m ) P (p | l, T m ) ∏ i = 1, 2 P (r n (i ) | seq m l p ) , where l is the length of a fragment, p is its position and seq mlp denotes the underlying reference sequence.
Similar(56)
Einstein was right about that last part, but he hadn't considered the much greater likelihood of alignments between bigger and brighter celestial objects — supernovas, whole galaxies or clusters of them.
"The computational experiment on the estimation the likelihoods of alignments of similar but evolutionarily unrelated sequences".
The z-score, SCI, and % sequence identity are used as input to an SVM (trained on known RNA alignments from Rfam) which decides the likelihood of the alignment being a functional RNA.
To infer these parameters from the data, we use a simple iterative approach [ 28]: Starting with an initial alignment, parameters are estimated so that the likelihood of the alignment is maximised.
We then calculated the likelihood of the alignment for each element and its associated repeat alignments jointly under a constrained model, and then separately under an unconstrained model.
The availability of greater coverage and longer contigs from the long march improves the likelihood of successful alignment and thus discovery of both known and novel organisms in a heterogeneous metagenomic sample.
The optimized π vector can give significant improvement over the likelihood of a alignment.
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