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Those formulations consist of a macrocycle like DOTA or NOTA combined with lanthanides like Tm, Gd or Ce [68,69].
9 Evidence indicates that single-component interventions like TM are efficacious in some conditions, 13 18 including HTN, 19 with possible long-term effects.
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Considering the similarities between the membrane structure of Borrelia and that of the Proteobacteria, we considered it likely that the OmpA-like TM domain would be conserved in both.
The unifying theme among all these receptors is their INSL3/Relaxin binding GPCR-like TM region.
To date, the OmpA-like TM domain has not been identified in Borrelia.
Protein sequences of all available OmpA-like TM domains were obtained from the Pfam database family PF01389 [ 42].
Nine cDNAs encoded typical cell surface proteins containing TM2-like TM regions and cytoplasmic tails of varying length with one to three tyrosine-based motifs (Fig. 2).
14 additional sequences belonging to this subfamily possess shorter N-terminal regions that do not contain any explicitly recognizable domains while bearing INSL3/Relaxin binding GPCR-like TM regions [Additional data file 3].
Sequences for the putative Borrelia OmpA-like TM domains were then added to this alignment and manually adjusted to match the topology and β-strand positioning as predicted by PRED-TMBB.
One sequence has a long C-terminal tail containing multiple non-DMT domains, and 91 sequences have no Pfam domain definition for the first "DMT slot", even though that area contains the same DMT-like TM helices as other annotated sequences.
The Q-factor is optimized for transverse-magnetic-like (TM-like) cavity modes, and it is found that a maximum Q ≃ 45000 can be reached by proper design of the pillars defining the cavity region.
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