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Recommendations for the Standardization of Light Transmission Aggregometry: A Consensus of the Working Party from the Platelet Physiology Subcommittee of SSC/ISTH.
Cattaneo M, Hayward CP, Moffat KA, Pugliano MT, Liu Y, Michelson AD. Results of a worldwide survey on the assessment of platelet function by light transmission aggregometry: a report from the platelet physiology subcommittee of the SSC of the ISTH.
The mechanism underlying their antiplatelet activity was elucidated by eliminating potential targets through a series of in vitro assays including light transmission aggregometry, clot retraction, and quantitative ELISA, further identifying the reduction in biosynthesis of thromboxane B2 as their main mechanism of action.
Assays included light transmission aggregometry (LTA), VerifyNow P2Y12 (VN-P2Y12), and vasodilator-associated stimulated phosphoprotein (VASP).
We used light transmission aggregometry (LTA) the gold standard method to monitor platelet function inhibition [11].
Using light transmission aggregometry with arachidonic acid, 10 patients had persistent platelet reactivity, corresponding to 45%% of the total population.
Similar(24)
Although light transmission platelet aggregometry is considered the standard test to assess platelet function, it is cumbersome and not generally available.
Platelet function testing was performed by light transmittance aggregometry.
Aggregation of washed-platelets was determined using light transmittance aggregometry (Chrono-Log Corp., Havertown, PA).
Platelet reactivity to adenosine diphosphate (ADP) by light transmittance aggregometry (LTA) was determined simultaneously.
Platelet function testing was performed by light transmittance aggregometry (LTA) on a Chronolog 700 Aggregometer (Chronolog Corp., Havertown, PA).
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