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Light obscuration measurements were performed on a HIAC Royco Liquid Particle Counting System Model 9703 with sensor model HRLD-150 and sampler model 3000A, equipped with a 1-ml syringe (Hach Company, Loveland, CO, USA).
Sensing principle is light obscuration.
These velocities were confirmed using light obscuration, pressure measurement and particle image velocimetry methods.
A technical implementation is presented; based upon the light obscuration signature, observed in the delivery path during drug delivery.
Soluble aggregates and subvisible particles were observed by size‐exclusion high‐performance liquid chromatography (SE‐HPLC) and light obscuration when formulated with suboptimal levels of polysorbate 20.
The Floc Size Distribution (FSD) of a sample from the reservoir is determined using a light obscuration instrument for a sequence of completed strokes in approximately geometric progression.
The same trends were observed by light obscuration (data not shown).
Light obscuration (LO) and membrane microscopy are the standard methods for measuring extrinsic particles >10 μm.
Light obscuration reported lower particle numbers that both the Coulter counter and flow microscopy.
Light obscuration and flow microscopy showed different sensitivities to protein concentration.
The light obscuration instrument was placed in a laminar flow hood.
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