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The finding that a considerable portion of the molecular clock is regulated by light in the central clock structure points to a more complex regulatory mechanism underlying light-entrainment of the circadian clock than previously appreciated.
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After sunset a bonfire was lit in the central fire pit and site manager John regaled us with tales about the forest.
A Tokyo Electric official said workers had managed to restore lighting in the central control room of Reactor No. 1, an important step toward restarting its cooling system.
This type of response is rare; the most usual ganglion cell or optic nerve fibre has a receptive field organized in a concentric manner, so that a spot of light falling in the central part of the field produces a discharge, while a ring of light falling on the surrounding area has the opposite effect, giving an off-response i.e., giving a discharge off-response ilight is switched off.e
A few film crews and artists who use the place as a backdrop know, as do the romantics who on the occasional misty evening, come and stare at the spectral light flickering in the central tower.
However, jet-lag did not significantly change the overall survival and tumor development of irradiated Bmal1−/− mice that were deficient in responding to circadian light cues in the central clock (Table 1, Fig. 2a, Fig. S1c and data not shown) [50].
But as far as brunello di Montalcino is concerned, it is left to consumers to try to recognize which wines come from the lower elevations and clay soils in the south, and which are from the higher, lighter soils in the central area around the town of Montalcino.
Hence, D-box enhancers appear to serve as key elements in light-driven signalling in both the pineal gland and cell lines, pointing towards a somewhat similar mechanism of light-entrainment in the central and peripheral clocks.
Many other genes and pathways are altered under low-P conditions, which is not surprising in light of the central role of P in living cells.
In light of the central role of Oct4 in pluripotency and the cancer stem cell hypothesis, we investigated which of Oct4's physical interactors are misexpressed in cancer using the Oncomine human cancer expression database.
In light of the central role that NSCs have in the developing and also adult nervous system, we designed the present study to investigate the molecular mechanisms responsible for the long-lasting effects induced by GCs in primary cultures of embryonic cortical NSCs.
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