In both the elevated plus maze and the light-dark exploration test, light levels were very low (see methods for details) in an attempt to maximize sensitivity for detecting potential anxiogenic effects of mGluR5 haploinsufficiency (we hypothesized that anxiety-related phenotypes may track with the OSS data).
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Considering the previously established anxiolytic phenotype of mGluR5 null mutant mice, EPM and light-dark exploration testing were conducted under low lighting conditions to enhance our ability to detect a potential anxiogenic phenotype in the heterozygous mice (Fig. 4).
Similar to results from EPM, we saw no significant differences between genotypes in the light-dark exploration test as measured by time spent in the light chamber (F 2,31) = 1.9, n.s).s
48 hours following elevated plus maze testing, mice were tested in the light-dark exploration test.
To investigate anxiety related measures in mGluR5 heterozygous and knockout mice, we tested them in elevated plus maze (EPM) and the light-dark exploration test.
34 male mice were tested on the elevated plus maze followed by the light-dark exploration test, then subjected to a modified Irwin screen.
At least one week following the light-dark exploration test, mice were screened for physiological and reflexive measures in a modified Irwin battery [45] using a three point scale similar to that previously described [46].
