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Results of the logistic regression analysis of haplotype-specific associations between lifetime water arsenic concentrations and BCC are shown in Table 4.
The adjusted odds ratio per 10-μg/L10-μg/Lse in average lifetime water iAs concentration was 1.18 (95% confidence interval: 1.08, 1.28).
We stratified the study population according to haplotype and used unconditional logistic regression to evaluate the association between average lifetime water arsenic concentration (per 10 µg/L increase, continuous variable) and BCC risk.
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Twenty-four field teams, each consisting of one man and one woman, moved from village to village and house to house examining the skin of all participants for skin lesions and interviewing them regarding lifetime water-consumption history.
The Interim Lifetime Drinking Water Health Advisory of the EPA recommends a provisional advisory drinking water limit of 15 µg/L perchlorate [9], with California having an enforceable standard with a maximum contaminant level of 6 μg/L perchlorate [10].
During the long lifetime of water infrastructure, all of these factors may evolve.
The exposure metric that showed the most significant relationship with BCC was lifetime average water iAs concentration.
Information on lifetime drinking water sources, swimming pool attendance, showering-bathing practices, and socioeconomic status (education, income) was collected through personal interviews.
Overall, 25% of the population had a lifetime average water concentration above 10 µg/L and 8% above 50 µg/L [Hough et al., 2010].
The association between iAs and BCC remained significant in the subgroup exposed to iAs lifetime average water iAs concentration < 40 μg/L (90th percentile).
BCC was positively associated with three indices of iAs exposure: peak daily iAs dose rate, cumulative iAs dose, and lifetime average water iAs concentration.
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