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Although many variables may be associated with cross-sectional telomere length at a single time point, reflecting the cumulative lifetime burdens of genetic and environmental exposures, most of these effects appear to be dwarfed by the apparent negative feedback from baseline telomere length to telomere trajectory.
Cross-sectional TL at a single age point reflects genetic background and cumulative lifetime burdens of environmental stress exposures (34), but the large inter-individual variation and unmeasured confounding factors, such as baseline TL and differences of somatic stem cell telomerase activity among subjects, may all account for the 'unexplained' lack of association.
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I was relieved the commission recognised how fractured current systems were and that a socially progressive policy might allay the lifetime burden on informal carers and genuinely help those with disabilities realise their dreams of being ordinary citizens.
Iceland is among those states that keep a tight rein on naming conventions, in part to protect children from bearing a lifetime burden as the result of fanciful choices made in the first flush of parenthood.
Higher rates of atherosclerosis, heart murmurs and other cardiac conditions among US soldiers in early 20th century were linked to higher lifetime burden of infectious disease, particularly respiratory infections and rheumatic fever [27].
These fundamental observations have led to increasing interest in telomere length as the possible basis for a "biological clock" which integrates the cumulative lifetime burden of genetic factors and environmental stressors independently of chronological age[5].
Figures 1 and 2 show the lifetime burden of morbidity by gender at any age.
The epidemiological transition from acute diseases, where the emphasis was on cure, to chronic illnesses that instead require management also means that patients take on a lifetime burden.
Many studies of diabetes have examined risk factors at the time of diabetes diagnosis instead of considering the lifetime burden of adverse risk factor levels.
8 16 To the best of our knowledge, there are no studies evaluating the lifetime burden of overweight and obesity on low back outcomes.
6 There is little evidence of improvement in psychological problems between 2 and 7 years post injury, 7 with survivors remaining largely dependent upon family support, thereby potentially imposing a lifetime burden on relatives.
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CEO of Professional Science Editing for Scientists @ prosciediting.com