Sentence examples for lifespan reduction from inspiring English sources

Inactivation of the Sirt7 gene in mice results in lifespan reduction and the mutant mice also develop cardiac hypertrophy and inflammatory cardiomyopathy (Vakhrusheva et al. 2008a, b).

This may suggest that inflammation-associated tissue damage contributing to lifespan reduction is carried through complete metamorphosis.

Normal human fibroblasts were benefited by treatment with i-Extract; these showed increase in lifespan, reduction in the molecular damage and protection against oxidative stress [27], [28].

However, the lifespan reduction is not drastic in normally fed flies, suggesting that GABA signaling may primarily inhibit IPC activity under specific conditions (as shown below).

The lack of lifespan reduction in the mitochondrial SOD mutants has been interpreted as a major challenge to the mFRTA [12], [24], [28], [32], [33].

Since phenoloxidase levels in our study did not appear to be upregulated in the long-term, we can confidently hypothesise that the observed lifespan reduction was not caused by repeated tissue damage from persistent phenoloxidase.

We can, in part, attribute our longer lifespans, reduction in infant mortality and childhood deaths from life-threatening infections, and the near elimination of childbirth-related maternal deaths from infections in hospitals to antibiotics.

CycD/Cdk4 expression driven by worniu-Gal4 was not larval lethal and did not influence lifespan, indicating that excess CycD/Cdk4 lifespan-reduction effect is adult neuron specific and limited to cells that express ELAV-GeneSwitch (Fig. S3).

Spermidine is a polyamine compound exhibiting important biological activities, such as increasing lifespan, inflammation reduction, and plant growth control.

It leads to delay in onset of clinical signs, a significant increase in lifespan, a reduction in cholesterol and ganglioside accumulation in neurons, reduced neurodegeneration, and normalization of markers for both autophagy and neuro-inflammation.

Surprisingly, when looking across 31 strains with varying CR lifespan effects, reduction in T b was a negative predictor of life-extension.