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Ger Tierney, executive fashion editor of i-D Magazine, said Moss's longevity was also partly down to a reaction against "the increasingly short lifespan of models' careers that has become a depressing norm.
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Similarly, autophagy inducing agent spermidine has been shown to extend the lifespan of model organisms (Eisenberg et al., 2009).
This reproducible approach gives a measure of metabolic stress resistance, a variable that often is related to lifespan of model organisms [36], [39], as shown in honeybees [32] [34].
These data suggest that miRNA expression patterns change with the lifespan of model organisms and indicate that different levels of miRNAs may directly affect the aging process.
Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR), robustly extends the lifespan of model organisms including mice.
The aforementioned results indicate that resveratrol and spermidine can prolong the lifespan of model organisms through the induction of autophagy.
Histone demethylation has been suggested to play an important role in the lifespan of model organisms [ 19, 20].
We thus studied whether resveratrol, a well-studied anti-aging agent [ 84], would extend the lifespan of model organisms via the induction of autophagy.
Sirtuins are a highly conserved family of histone/protein deacetylases whose activity can prolong the lifespan of model organisms such as yeast, worms and flies.
Many studies have addressed the question of supplementation with antioxidant vitamins, especially vitamins C and E, and synthetic compounds can prolong the lifespan of model animals.
During the past two decades, several interventions have been shown to increase the healthy lifespan of model organisms as evolutionarily distant from each other as yeast, worms, flies and mammals.
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