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SGK-1 inhibits SKN-1 nuclear accumulation directly, through phosphorylation, and sgk-1 RNAi has been observed to increase lifespan dependent upon skn-1 (Tullet et al., 2008).
Administration of sgk-1 feeding RNAi throughout the life cycle was reported to extend lifespan, dependent upon both daf-16 and skn-1 (Hertweck et al., 2004; Tullet et al., 2008).
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The increased lifespan is dependent on pha-4/FOXA and partially dependent on skn-1/NRF2.
In a background of C at the 1177 position, Lim3A transcription and Drosophila lifespan was dependent on the G871C marker (Table 4).
► sod-2 (MnSOD) over-expression effects on lifespan are dependent on DAF-16.
► sod-1 over-expression effects on lifespan are dependent on DAF-16 (FoxO) and HSF-1.
Metformin Effects on Worm Lifespan Are Dependent on Bacterial Type, Related to Figure 3 Table S4.
The O-GlcNAc-mediated effect on nematode lifespan is dependent on the FoxO transcription factor DAF-16.
If infected, each bird's lifespan is dependent on the virulence of the infecting virus and its own vaccination status.
However, data suggest that effects of metformin on lifespan are dependent on genotype, gender, biguanide type, dose and duration of the treat-ment.
Therefore, activation of AMPK is not always coupled to that of FoxO, even though AMPK's ability to extend lifespan is dependent on the presence of FoxO (Greer et al., 2007).
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