Exact(7)
Lifespan decrease in normal flies due to autophagy inhibition is consistent with previous observations in mice[10], [11], confirming the importance of normal autophagy for animal survival.
Neuron-specific Atg5RNAi expression also results in a lifespan decrease for control flies and again a significant lifespan extension for Aβ1 42 flies (Fig. S8A).
In particular, Forster et al. [46] reported a series of experiments in which long-term caloric restriction increased lifespan in B6 mice and B6D2F1 hybrids, but led to a slight lifespan decrease in mice of the DBA strain.
For OregonR only, the highest food concentration caused egg laying to decrease, which indicated that the associated lifespan decrease from 1.5× to 2× was not accompanied by increased intake of biologically valuable nutrition and therefore could be due to a non-specific detrimental effect of high food.
However, this study showed that, while the strain expressing Ty1 element had 40-fold increased mobility to the rDNA region, neither Ty1 mobility nor increased mutation rate of a representative Ty1 gene led to chronological lifespan decrease.
However, the PCNA-BD does not appear to be important for the cell cycle regulation function of CS-like phenotypes in yeast because rad2C38Δ did not confer a growth defect, lifespan decrease, or any morphological changes after UV damage.
Similar(53)
The amount of time that a star spends on the main sequence depends primarily on its mass, with the lifespan decreasing with increasing mass.
As food availability is increased beyond this point, lifespan decreases via the DR response.
Given that lifespan decreases with ambient temperature, a straightforward explanation is that increased wasp density also results in increased ambient temperatures and, consequently, in reduced lifespans (Figures 3, 5).
There is evidence that the mechanism behind these changes is the decreased brood size of multiple foundresses, combined with the fact that females lay most male eggs early on [65], which is consistent with our finding (Figure 3) that effective lifespan decreases with foundress number.
With rapidly decreasing UVR at conception, lifespan decreased in the better-nourished, white, female diabetic population.
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