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Our results likewise indicate that early and late deaths have different implications for the variability of lifespan conditional on survival to successive ages.
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Upon further examination, we found that the ability of the intestinal daf-16 to extend wild-type lifespan was conditional on the food source and had a small but opposite effect when worms were fed on OP50 bacteria.
The results below demonstrate how the pattern of mortality improvement over time – as reflected in changes in the Siler model parameters – differentially affects lifespan variability conditional on survival to younger and older ages.
Life is conditional.
In contrast to these results, lifespan was shortened by conditional expression of dilp6 with ubiquitous drivers, as well as when dilp6 was ubiquitously reduced by RNAi (Table 1; Figs S3 and S4).
Under certain experimental conditions, the lifespan effects of ectopic dfoxo expression can be conditional on the nutrients available to the animal (Bai et al., 2012, Min et al., 2008).
Understanding : Participants were shown seven cards, each addressing one of median survival, remaining lifespan, absolute survival, relative survival, conditional survival and a graph (two cards).
The three-component Siler model, however, can produce a pattern of compression in lifespan variability accompanied by increasing variability conditional on survival to older ages.
(The conditional is a condition.
Similarly, taking f y| a) as the conditional density of remaining lifespans, one may calculate the variance of age-specific remaining life spans (thanatological age), where e(a) is remaining life expectancy at age a: The variance of y given survival to age a is and this function will have some non-monotonic pattern over age (in human populations) that remains to be explored.
Lifespan was not affected when dilp6 was over-expressed by a conditional pan-neuronal driver or when silenced by RNAi in fat body (Table 1; Figs S3 and S4).
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