Exact(34)
Progeny from this cross with no MMP-9 exhibited an 80-day delay in loss of fast-fatigable motor neuron function and a 25percentt longer lifespan, compared with littermates with two copies of the MMP-9 gene.
Treatment of CL2006 worms having muscle-specific expression of Aβ with 50 μM of Ot B caused a significant increase in their lifespan compared with controls (p < 0.005; Fig. 1b, Supplementary Table 1).
Aβ1 42 flies with the Atg1+/− genotype have a 10.9% increase (log-rank P<0.0001) in mean lifespan compared with Atg1+/+ genotype (Fig. 8B).
In summary, our study revealed that the clonal grass of L. chinensis had a relative short overall root lifespan compared with root lifespan values for other plant species (including grass of S. krylovii) in the same temperate steppe.
In contrast to Aβ1 42 flies, control flies with the Atg1+/− genotype have a 13.6% decrease (log-rank P<0.0001) in mean lifespan compared with Atg1+/+ genotype (Fig. 8B).
We additionally found that our zprelamin A fish cohorts (no genders identified; n = 36) manifested a shorter lifespan compared with that of their wild-type siblings (no genders identified; n = 91; P<0.0001, log rank test) (Fig. 8).
Similar(26)
The observation that two outcrossed strains harboring independently isolated sgk-1 null mutations both have short lifespans compared with wild-type animals strongly suggests that these short lifespan phenotypes are a consequence of reduced SGK-1 activity.
Mice that were missing one of these genes and were subjected to inflammation early in life showed signs of accelerated aging and had shortened lifespans compared with normal mice.
Overexpressing DM20, an isoform of PLP, knock-in mice (Stecca et al., 2000; Spörkel et al., 2002) have near-normal lifespans compared with shortened lifespans of different overexpressing PLP mouse lines (Mastronardi et al., 1993; Kagawa et al., 1994; Readhead et al., 1994; Bradl et al., 1999).
Only mutant females showed significant changes in lifespan compared to controls, with opposite effect seen in unmated and mated females.
Moreover, patients with low functional capacity before starting chemotherapy had significantly more disease progression and significantly shorter lifespan, compared to those with a higher functional capacity.
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