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"lifelong question" is a correct and usable phrase in written English
You can use it when referring to a question or issue that has been asked, considered, or pondered for a long period of time, often many years. For example, "The question of why we exist has been a lifelong question for many people."
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Steeped in harrowing recollections that evoke "The Painted Bird" and "Sophie's Choice," the tour starts in Krakow, Poland, where Avner finds proof of his birth and his family in archives, answering a lifelong question of identity.
This week Noah St. John answered a lifelong question for me.
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Among those who might have enriched and complicated Challenger's arguments are the ecofeminist theorists and Bruce Chatwin, who wrote about Tierra del Fuego in In Patagonia, and pondered lifelong questions of savagery, nature and culture.
In DS, in which intellectual disability is lifelong, the question arises as to how changes in cognition and functioning can be reliably related to the emergence of AD symptomatology.
Trying to get at that idea of cinema as opposed to, say, being overwhelmed by the screens that surround us every waking hour — inundating us in undifferentiated visual noise — suggests why Mr. Jones wanted to fold into this year's festival a comprehensive Godard retrospective, one that would showcase an entire lifelong engagement with questions of cinema.
Thus began an extraordinary marriage, one bound together by love, respect and a shared lifelong struggle with the question of God.
I would love to believe that the Holy Spirit worked a miracle in his life, and he had a vision of the harm he had done and began to question his lifelong, faithful commitment to cruelty, impervious to the feelings of others.
They were so good, I questioned my lifelong loyalty to the hamburger side of America's great cookout divide.
This helps address the question of whether lifelong ART might be beneficial for all pregnant women.
Using shRNA (small-hairpin RNA -mediated knockdown of Nox4, implicating lentiviRNA -mediatedwe addressed the question of whether lifelong depletion of Nox4 in HUVECs would influence the senescent phenotype.
At the ceremony on Thursday, Sheri Fink's "extraordinary reconstruction" of the days following Hurricane Katrina, Five Days at Memorial, won the NBCC non-fiction prize, and Frank Bidart took the poetry award for his collection Metaphysical Dog, "which continues his lifelong exploration of the big questions", said the NBCC.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com