The fatigue life is calculated using the modifications of the Palmgren Miner Original rule, according to the Palmgren Miner Elementary method, as well as to Haibach's suggestion.
Quality of life is calculated using a formula that assesses mobility, self-care, everyday activities, depression/anxiety and pain.
Final expected value for quality of life was calculated using a "rollback" technique.
Quality of life was calculated using the utility formula from Göhler et al 14 using the baseline characteristics of the patients in the EMPHASIS-HF trial.
Average PM2.5 concentration in the first 3 months of life was calculated using data from the Monterey Unified Air Pollution Control District MBAPCDD) air monitoring station, which uses high-volume Sierra-Andersen gravimetric samplers for 24 hr every sixth day (Thermo Scientific, Waltham, MA).
The second quality indicator, "the proportion with more than one hospitalization in the last 30 days of life", was calculated using "the number of patients who died from cancer and had more than one hospitalization in the last 30 days of life" as the numerator and "the number of patients who died from cancer" as the denominator.
To evaluate the dose dependence of the pharmacokinetic behavior of sirolimus, AUC0 ∞ and half-life were calculated using a noncompartmental pharmacokinetic analysis implemented in the PK Solutions software (version 2.0; Summit Research Services, Montrose, CO).
Activities were measured using a Capintec dose calibrator and half-life was calculated using Eq. (1).
The blood half-life was calculated using Prism 6.0c (GraphPad Software, La Jolla, CA).
Protein half-life was calculated using the following equation, where N0 is the initial quantity, Nt is the quantity that still remains after time t, and λ is the decay constant.
