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Future developments to the model could include: the addition of clinically relevant health states such as dysplasia and cancer stage, the incorporation of risk factors, and quality of life utilities and cost.
All other quality of life utilities used in the base case simulation have been described previously by Palmer et al. [ 19].
Table 1 presents quality of life utilities (EQ-5D and ASCOT) and summary scores (OPQol-Brief) according to demographic and other participant characteristics.
Therefore it was important to perform appropriate sensitivity analyses to explore the robustness of projected outcomes to changes in the quality of life utilities assumed in the current analysis.
15 A series of univariate analyses were carried out on some parameters of the simulation model, including variation in quality of life (utilities) and the cost of the single-tablet regimen, and identifying the threshold value for these parameters.
In the base case scenario quality of life utilities were taken from CODE-2, and for many events such as oedema and heart failure this resulted in no disutilities being applied due to the absence of data.
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"Religion and poetry address themselves, at least in one of their aspects, to the same part of the human constitution; they both supply the same want, that of ideal conceptions grander and more beautiful than we see realized in the prose of human life" ("Utility of Religion," Three Essays, p. 419).
The ICER for the quality of life utility score represents the cost per QALY gained.
The Assessment of Quality of Life (AQoL 8D) is a health-related quality of life utility measure.
The primary outcome measure was quality adjusted life years (QALYs) with Health Utilities Index Mark 3 health related quality of life utility scores as the quality adjustment weights.
Health benefits are measured in QALYs, which are defined as the product of life years and a preference-based index of quality of life (utility weight).
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