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We argued over whether a new drug that shrank a tumor for several weeks but didn't make women live longer, or improve their quality of life -- and had life threatening side effects -- was good enough.
Stem cell transplantation to cure the progressive bone marrow failure is challenging, and DKC patients have a poor tolerance for conditioning regiments and frequently suffer from life threatening side effects [ 24– 26].
The psychoactive nature of these compounds, and their potentially life threatening side effects, limit their utility, but this work nevertheless provides a strong theoretical basis for future drug development.
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Cytotoxic chemotherapy or radiotherapy of cancer is limited by serious, sometimes life-threatening, side effects because of the lack of specificity to target cells alone.
Not only are these expensive, but they can, themselves, have life-threatening side-effects.
It did not refer to "new studies" as Susanne Moore put it but merely reported the cases of two patients for whom this treatment had brought life-threatening side-effects.
Trials are generally safe: if the treatment isn't working or if severe or life-threatening side-effects arise, patients may leave the trial or the trial may be cancelled.
Issues with high toxicity, life-threatening side-effects, cost, parenteral administration and emergence of resistance are drawbacks common to existing antileishmanial drugs such as sodium stibogluconate, meglumine antimoniate, pentamidine and amphotericin B [ 4, 8].
Due to the risk of potential life-threatening side-effects some authors recommend baseline and follow-up electrocardiograms (ECGs) throughout treatment with tricyclic antidepressants (Dworkin, Backonja et al 2003).
Also, Gleevec has potential life-threatening side effects.
Potentially life-threatening side effects can necessitate discontinuation of therapy.
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