Exact(1)
The hypothesis that cancers are maintained by a subpopulation of stem or progenitor-like cells while non-stem/progenitor cells have a finite life span raises the possibility that targeting specific components of the regulatory pathways of cancer stem cell maintenance could provide a means of cancer control.
Similar(59)
The heavier birth weight of babies born to some diabetic pregnancies is reflective of this process, where the stressed pancreas accelerates growth via the anabolic actions of insulin (18); this process is also hypothesized to diminish the capacity of the pancreatic β-cells to function adequately across the adult life span, thus raising the trajectory for diabetes even before the baby is born.
Given that mutations in daf-9 as well as daf-12 alter longevity, the findings provide some of the first evidence that a steroid molecule influences life span--raising the prospect that similar steroid hormones might play an analogous role in humans.
Photo: Senator Chuck Hagel, Republican of Nebraska, entered the Social Security debate yesterday, offering a plan to reduce benefits by tying them to life expectancy, meaning that all monthly checks would drop as the average life span grew, and raise the retirement age to 68 from 67. (Photo by Doug Mills/The New York Times).
The availability of large numbers of susceptible piglets and short overall life span of pigs raised for meat production also ensures that the host immune pressure on the virus is less marked in pigs than in humans.
Because telomerase restores DNA to the ends of chromosomes, repairing age-related chromosomal fraying and extending the life span of cells, the discovery raised hopes of finding new treatments for cancer and aging.
However, the doses used to achieve life span extension were very high, raising the question of this compound's bioavailability.
When C. elegans is cultured in low oxygen, its life span is extended [ 34], raising the possibility that HIF-1 may promote the longevity of the animal.
But limitations like differences in intestinal morphology, enteric microbiota, body mass, life span and different food intake raise concerns about the suitability of the rodent model.
The effect of Nef on life span of nematodes was analyzed by raising the worms on normal or Nef treated medium right from the embryonic stage (embryos isolated as per [10]).
Whatever Klotho's ultimate mechanism, the work raises the intriguing possibility that life span can be extended despite or perhaps via mild insulin resistance, a trait long considered deleterious to longevity.
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