Sentence examples for life span effects from inspiring English sources
Several genes that regulate life span (e.g., Superoxide dismutase, Catalase, and rosy) complemented the life span effects of wild-derived alleles, suggesting little natural variation affecting longevity at these loci, at least in this sample of alleles.
The tissue-general driver facilitated the screening of senescence and apoptosis regulatory genes for life span effects.
It is often desirable to over-express a gene in all the tissues of the fly, for example when screening genes for possible life span effects.
To definitively rule in (or out) a role for IIS in Drosophila p53 life span effects will require future assays in the presence and absence of the Foxo transcription factor.
These results underscore the importance of careful controls for possible life span effects on the conditional gene expression system itself, independent of the specific identity of the gene being over-expressed.
The potential importance of the cellular senescence and apoptosis pathways in modulating life span prompted a screen of additional genes implicated in these pathways for life span effects in the fly.
Following up on his lab's initial observation that SIR2's life span effect could disappear in outcrossed worms, Gems teamed up with Matt Kaeberlein at the University of Washington, Seattle, and Linda Partridge of University College London, both of whom have previously questioned the role of sirtuins in aging.
These considerations limit the support for a possible negative life span effect of the Vg transgenes as suggested in the Abstract and Discussion.
The life span extending effects of DN-Dmp53 are furthermore smaller than the life span extending effects of CR.
Interestingly, the multitude of biological effects (fecundity, activity, etc). of CR can be uncoupled from the life span extending effects of CR. dSir2 over expressing flies, while having extended life span, do not show any defects in fecundity.
These data suggest that the life span extending effects of CR in flies are mediated at least in part by dSir2, while the effects on other physiological systems may branch off at points up stream of dSir2 in the CR signaling pathway [ 7].
