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Information on the link between insulin/IGF-1 or mTOR signaling and ER stress in life span determination remains limited.
One general area that has been implicated strongly in aging and life span determination is nutrient availability/sensing.
A concise list of genes in the region that are implied in life span determination includes chico, DNA methyltransferase 2, Sir2, tamas, Target of rapamycin, bubblegum, Myosin 31DF, porin and Pten, whereas Hsp60D is involved in the response to heat.
The elucidation of the mechanisms that underlie the sexual antagonistic pleiotropy demonstrated in this study will be of great interest both to studies of life span determination and evolution of antagonistic functions within a single gene.
This adds to the complexity of how p53 governs life span determination; contrasting scenarios report high tumor incidence in p53 knockout mice, thus shortening life span, while p53 overexpression induces accelerated aging [ 38, 39].
The complexities presented here in p53-dependent regulation, and how miR-34a participates in this puzzle for brain aging, will demand future system biology investigation to unravel their mysterious but fascinating roles in regulating aging and life span determination.
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The list of genetic factors pertinent to life-span determination has been growing by leaps and bounds, to define age-related physiological changes [ 1].
Although our results are reminiscent of such transcriptome modulation, in striking contrast, we observed no enrichment of ILS or BPs involving life-span determination.
Moreover, due to short life span, easy to quantitative determination and rapid response to pollutants algae act as a bioindicator of water quality changes.
These include reproduction, development and determination of life span [11], [24].
Nevertheless, many other ESTs are predicted to be involved in processes such as development and functioning of the nervous system, reproduction, determination of life span and growth.
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