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"We have to look at early life exposures, in utero, childhood, puberty, pregnancy and lactation," Ms. Rizzo said.
To investigate the possible correlation between maternal characteristics, in utero and early neonatal life exposures, and the development of endometriosis in adult life.
An increasing number of reports suggest early life exposures result in adverse effects in offspring who were never directly exposed; this phenomenon is termed "transgenerational inheritance".
There is evidence to suggest that early life exposures influence epigenetic mechanisms associated with adult disease risk [31], [32].
Logistic regression models defined independent effect of early life exposures, adjusting for potential confounders.
Epigenetic gene regulation is a proposed mechanism by which early life exposures affect later health outcomes.
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"I can't look at early-life exposures and prostate risk in humans," Dr. Prins said.
To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease susceptibility later in life.
Early-life exposures to stress especially during pregnancy, humiliation or misleading parenting can alter normal epigenetic programming in the brain, with overwhelming consequences for gene expression and behavior (Khulan et al., 2014; Szyf, 2011; Wu et al., 2014).
Both prenatal and early-life exposures have been postulated.
One important step is to employ real-life exposures.
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