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Circling through four chords with a jabbing lead-guitar lick, "Time Is Right" was a new song that sounded as if the Feelies had never disappeared.
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In antinociceptive test, BtOH and EtOAc fractions significantly reduced the writhing number evoked by acetic acid injection and the licking time in both phases of the formalin test.
Polysaccharide pretreatment significantly reduced the number of writhes and licking time but did not increase the latency time of responses, demonstrating its antinociceptive effects39,40.
Morphine (5 μg) microinjected unilaterally into VLO significantly inhibited the agitation response and the licking time, and these effects were blocked by pre-administration of the non-selective opioid receptor antagonist naloxone (1.0 μg) into the same site.
In the formalin test, these compounds at dose 178 µmol/kg p.o. reduced the licking time only in inflammatory phase of this test, suggesting an antinociceptive effect dependent of the anti-inflammatory effect.
We found that both subcutaneous (s.c., 300 ng) and intrathecal injection (i.t., 3 ng) of recombinant IL-33 (rIL-33) increased paw lifting and licking time not only in normal mice but also in formalin models.
Table 2 demonstrates that both the extract doses (200 mg/kg & 400 mg/kg) were responsible for attenuating hind paw licking time significantly (p < 0.01, p < 0.001) where the percentages of inhibition of hind paw licking were 53.95% & 71.62% during early phase and 61.79% & 78.8% during late phase respectively.
Morphine decreased the licking time during both phases.
Antinociceptive activity was calculated as the percentage inhibition of licking time.
Morphine reduced the licking time 47.33 and 70.74 % during early and late phases respectively.
The percentage of paw licking time inhibition of VRC in both phases indicated that it possessed potential inhibitory activity.
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