Sentence examples for licensing factor from inspiring English sources

OsMADS13 was also connected to PROLIFERA (PRL) which encodes a DNA replication licensing factor Mcm7.

The primers (Tf1_F/R) specific to detection of DNA replication licensing factor gene of T. flavus were designed.

Min et al. [34] identified GM-CSF to be a major licensing factor of CD8+ T lymphocytes to activate DCs during priming in lymphoid tissue, providing a positive feedback loop in the stimulation of CD8+ T cell proliferation.

DNA replication licensing factor CDC47 is a factor that helps the DNA to undergo a single round of replication per cell cycle.

Proteins regulated only after chloroquine treatment include for example the conserved protein PFC0135c and the DNA replication licensing factor mcm5, which were both upregulated by more than fivefold and quantified with five or four peptides, respectively.

Members of this group included primase and extension DNA polymerases, several associated repair enzymes, DHFR-TS as well as the DNA clamp proteins licensing factor C (clamp loader) and proliferating-cell-nuclear-antigens 1 and 2 [33], [33].

Moreover, the upregulation of the DNA replication licensing factor MCM3, which interacts with RAD51 and is directly involved in ATM/ATR checkpoints in mammals [32], [105], [106], might indicate the activation of cell cycle G1 and/or S checkpoints.

We have examined expression of the standard proliferation marker Ki67, the DNA replication-licensing factor Mcm2 and the repressor of origin-licensing Geminin during the proliferative cell cycle, using a novel, nonchemical method for cell synchronisation (membrane elution; Thornton et al, 2002; Helmstetter et al, 2003; Figure 1C).

In total cell extracts prepared from these synchronous batch cultures, protein levels of the DNA replication-licensing factor Mcm2 increase linearly in early G1 phase up to a maximum in S phase before decreasing during the latter part of the cell cycle.

The replication-licensing factor minichromosome maintenance protein 2 (Mcm2) is a marker of proliferative potential shown to be a promising prognostic marker in various malignancies.

Moreover, we have previously demonstrated that expression of the Mcm2 origin-licensing factor rises with increasing tumour grade and other markers of proliferation in this tumour type (Wharton et al, 2001).