An initial library comprising 11 inhibitors was developed and screened against six selected aspartic proteases.
A combinatorial library comprising 64 ligands based on the Ugi reaction was prepared and screened for binding GFP-tagged and non-tagged proteins.
For this purpose, the three PDZ domains were first screened for binding with a peptide library comprising 6223 human C termini created by SPOT synthesis.
A library comprising 44 diversely substituted aurones derivatives was synthesized by straightforward aldol condensation reactions of benzofuranones and the appropriately substituted benzaldehydes.
The FPP sequence was derived from a structurally diverse Phylomer phage-display library comprising hundreds of millions of sequences (so-called Phylomers) of microbial and viral genomic origin [41,42,43,44].
Grolier's library, comprising more than 3,000 volumes, was noted for sumptuous gilt and painted bindings, many stamped with his generous motto "Ioannis Grolierii et amicorum" ("For use by Jean Grolier and his friends").
To investigate these potential functions, the authors designed and used a protease substrate fluorescence resonance energy transfer (FRET) library comprising 115 short d- and l-amino-acid-containing fluorogenic substrates as a tool to generate proteolytic profiles for a wide range of bacteria.
To this end, developers can use the framework's provisioning support, which contains the APIs, provided by the provisioning agent, and a provisioning library comprising a number of functions that facilitate provisioning of the software-defined gateways.
As a part of the screening initiative, a library comprising more than 10,000 chemicals was screened in high-throughput assays against a panel of 12 different biological targets involved in two major groups of biochemical pathways: the nuclear receptor pathway and the stress response pathway.
Next, we obtained a focused siRNA library comprising several known clock components.
In order to identify histone demethylase inhibitor templates, we applied this assay for high-throughput screening of a diverse compound library, comprising the Molecular Libraries Small Molecule Repository (MLSMR) and additional collections, against the 2OG-dependent histone demethylase JMJD2E (KDM4E).
