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All styryl compounds in the particular library analyzed in this study shared the same molecular scaffold and therefore possessed many features in common (Figure 2).
The chemical diversity of the kinase inhibitor library analyzed here, compared to 11,577 protein kinase inhibitors retrieved from ChEMBL exhibiting IC50 values lower than 10 μM, is shown in Additional file 1: Figure S1 with diverse structures being visualized.
PKCparticipated in sequencing the UCHC library, analyzed data, and contributed to the manuscript.
SKWsupervised sequencing the UCHC library, analyzed data, and contributed to the manuscript.
SIK prepared the shotgun deep sequencing library, analyzed the deep sequencing data, and helped revise the manuscript.
These characteristics highly resemble those of a non-barcoded input library analyzed in two different sequencing reactions.
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We provide here an updated reference protocol for the production of 5C libraries analyzed by next-generation sequencing or onto microarrays.
Nevertheless, the libraries analyzed by Langdon et al. are rarely used in practical VS and the numbers of molecules in three libraries are even <10,000, and therefore the results may not be informative for drug design/discovery.
Many of the single transcript-tags came from MD 80228, which had the highest bacterial diversity profile of all libraries analyzed, and from MD 84730.
The yeast nucleosomal DNA sequence libraries analyzed in this study were derived from nucleosome occupancy experiments performed by Mavrich et al. 2008 [8], Weiner et al. 2009 [14], and Kaplan et al. 2009 [12009
Libraries analyzed are listed in Table 1.
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