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The model predicts that the liability threshold may be met by inherited factors alone or require additional random genetic and epigenetic events including environmental events during development.
We estimated tetrachoric correlations from a standard liability threshold model [50].
The percentage of genetic variance was estimated under a liability threshold model [23], [24].
For binary traits, the variance explained is computed based on the liability threshold model.
Using a liability threshold model, we estimated that the 10 risk loci account for only11.6% of the genetic variance in psoriasis.
To estimate the percent of variance explained by each of the psoriasis risk alleles, a previously described liability threshold model was used [26], [27].Our data show that HLA-C, IL12B and TNIP1/ANXA6 were estimated to account for 6.7%, 1.3% and 1.0% of the genetic variance, whereas the remaining loci each accounted for less than 1% of the genetic variance (Table 4).
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This argument could fuel the debate on the liability thresholds that might be introduced for re-use conditions.
Furthermore, the reluctance to adopt formal farmers' privileges in patent laws themselves can be overturned through jurisprudential liability thresholds, especially if plant-breeders' rights recognise growers' right to save and exchange seeds, as established before Canadian courts.
In contrast, the model parameters for brain structure (including liability thresholds) as well as the relationship with Sz are free parameters to be estimated from the data.
The effect of age was accounted for through regression coefficients on the liability thresholds, as has been described previously; 22 in the current study, these allowed for linear and quadratic effects of age, separately for each gender.
The liability thresholds have been set too low.
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