The tumor-associated antigen Ley is expressed on the majority of human epithelial tumors.
During human development, Ley is expressed on tissues of the fetus, placenta [9] and newborn [10], [11].
Even though there is a considerable intra-individual variability, it appears that there is a selection for maintaining the fucosyltransferase genes on so that both Lex and/or Ley are expressed.
Ley is an attractive target since it is expressed by most NSCLC.
Lewis Y (Ley) is a blood group-related carbohydrate that is expressed at high surface densities on the majority of epithelial carcinomas and is a promising target for antibody-based immunotherapy.
Lewis x (Lex) and Lewis y (Ley), the dominant Lewis antigens in H. pylori LPS, are expressed by 80 90% of clinical isolates [13] [16].
The original HPAG1 isolate, used for mouse infection, produced Ley, and no Lex, arguing that the futC gene must be expressed.
Alternative tumour-associated antigens with wider applicability include Lewis Y (LeY), a difucosylated carbohydrate antigen, which has poorly defined functions, but is expressed on a wide range of malignancies, including certain forms of AML, but has only limited expression on normal tissue.
Except for a presence on epithelial cells, such as keratinocytes, Ley/H appear to be endothelium specific and, moreover, are expressed selectively in synovium, lymphoid organs, and skin.
The Chao Ley are the indigenous tribe.
