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Significance of single or multiple effect of the main treatments with five levels was assessed using Duncan's multiple range test (DMRT).
Heterogeneity in effect sizes between factor levels was assessed using the test statistic QM (Appendix S3, Equation 6).
The relation between MUC1 and VEGF mRNA levels was assessed using the spearman correlation coefficient.
The correlation between age and serum collagen IV levels was assessed using the Spearman's correlation coefficient.
Intra- and inter-patient variability of antiretroviral drug levels was assessed using coefficient of variation and intra-class correlation.
The relation between the lifetime cumulative number of menstrual cycles and hormone levels was assessed using analysis of covariance.
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Kiss1 mRNA levels were assessed using an in situ hybridization (ISH) protocol described by us previously [ 22, 30].
One week after the first dose, blood glucose levels were assessed using a glucometer.
The correlations of the two HbA1c levels were assessed, using Pearson's correlation coefficient.
Plasma PCSK9 levels were assessed using ELISA at the end of each phase.
Their pain levels were assessed using the Visual Analogue Scale (VAS).
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